SAM-e 400 mg – 60 Tablets

Jarrow Formulas® SAM-e 400 – provides a full net amount of 400 mg of SAM-E, derived from 800 mg of SAM-E tosylate disulfate. This product is manufactured according to best manufacturing practices for SAM-E, at low temperature and low humidity, and is enteric coated to ensure a biologically active product. SAM-e has undergone numerous clinical studies involving thousands of patients. Researchers have identified many structural and functional benefits of SAM-e, involving over 40 biochemical processes with a variety of effects on the body, including improved liver function, increased cartilage formation, and improved mood.

SAM-E has been clinically proven to have the following benefits:

Joint Health: SAM-E supports the production of healthy connective tissue through transsulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-E metabolites to produce sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.

Brain metabolism: The methylation effects of SAM-E are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, adrenaline, and phosphatidylcholine (a component of lecithin).

Liver: SAM-E metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances critically important for liver function, including phase II detoxification.

Not all SAM-e products are the same

SAM-E exists in two forms: (S,S) SAM-E and (R,S) SAM-E. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive (but widely used in supplements).

Jarrow Formulas® SAM-e is primarily in its active form. It is naturally produced through microbiological fermentation, then specially processed, without solvents, to retain 68-80% (S,S) SAM-E, the highest active level available.

SAM-e is a very fragile and highly reactive molecule. It degrades rapidly at high temperatures or humidity. Improper handling of SAM-e can lead to degradation within a few hours.

Therefore, Jarrow’s technological superiority allows the use of a special method in which production is carried out under conditions of low temperature and low humidity. Each tablet is enteric-coated and blister-packed to ensure the highest possible bioavailability and safety for SAM-e available on the market. Pharmacokinetic studies have shown that taking SAM-e supplements is most effective when an enteric coating of special gastro-resistant fluid polymers is present.

Honors and Awards: Jarrow’s SAM-e product is ranked #1 in sales in the natural products channel for 52 weeks, as reported by SPIN, a market research and consulting firm for the Dietary Supplement Industry. Jarrow Formulas was one of the first companies to produce SAM-E, giving the company the most experience in producing this unique product.

Keep out of the reach of children.

Recommended dosage: 1 tablet daily on an empty stomach or as directed by your qualified healthcare professional.

Note: People using prescription medications such as antidepressants, including Selective Serotonin Reuptake Inhibitors (SSRIs) and MAOIs, should consult a physician before using SAM-e. Patients with Parkinson’s disease, bipolar disorder, or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed the recommended dosage. In rare cases, it may cause gastrointestinal upset in some individuals. If you experience discomfort, discontinue use.

Other ingredients: Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, and enteric coating (methacrylate copolymers, magnesium silicate, titanium dioxide, triethyl citrate, silicon dioxide, and riboflavin).

Does not contain: Wheat, soy, gluten, dairy, eggs, fish/shellfish, peanuts or tree nuts.

Jarrow Formulas ® SAM-E 400 is packaged in a foil blister pack to maximize stability and safety. Do not use if the outer blister pack is damaged.